The Reset Bone Ageing project intends to develop a coating for orthopedic devices with the ability to “rejuvenate” the aged bone tissue and increase its capacity for regeneration. This coating will offer competitive advantages over other strategies documented in the literature, such as cell therapies, in terms of production, cost and ease of use. The coating consists of the physical immobilization of extracellular vesicles (negatively charged negative) on the surface of titanium orthopedic devices by an antimicrobial peptide (positively charged). peptide (positively charged). The peptide serves as an anchoring point for extracellular vesicles isolated from Wharton Jelly mesenchymal cells. The development of the coating comprises several steps, from the development of processes to immobilize the peptide on the surface of the device medical device with the density, orientation and stability, the establishment of protocols isolation of EVs from mesenchymal cells and their characterization in in vitro assays in vitro assays, the development of interaction protocols between the peptide and that the vesicles are not destroyed and that the complex is maintained in contact with contact with blood, and the demonstration that the coating possesses anti-aging properties in in vitro and in vivo tests.